Silodosin

Iupac Name：1-(3-hydroxypropyl)-5-[2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2,3-dihydroindole-7-carboxamide

CAS No.: 160970-54-7

Molecular Weight：495.53

Modify Date.: 2022-11-22 15:43

Introduction: Silodosin, an a1A adrenoceptor (a1A-AR) antagonist selective for prostaticreceptors, was launched as an oral treatment for dysuria associated withbenign prostatic hypertrophy (BPH). The regulation of smooth muscle tone in thebladder neck and prostate is thought to be primarily mediated by a1A-AR.Blockade of these receptors can cause smooth muscle relaxation in these areas,resulting in improved symptoms and urinary flow rates. Conversely, a1B-AR arelargely located on vascular smooth muscle, and antagonism of these receptorscan cause tissue relaxation and potentially decrease cardiac compensation mechanismsinvolved in regulating blood pressure.