HomeProductSacubitril
Sacubitril
936623-90-4
LCZ696
99 %

LCZ696

CAS No.: 936623-90-4
Molecular Weight:847.026
Modify Date.: 2024-04-16 23:36
Introduction:
LCZ696, with the chemical formula C24H29N5O3, is a compound with CAS registry number 936623-90-4. It is a combination drug used for the treatment of heart failure. LCZ696 consists of two active components, sacubitril and valsartan. Sacubitril inhibits neprilysin, an enzyme that degrades natriuretic peptides, leading to increased levels of these peptides, which promote vasodilation and diuresis. Valsartan is an angiotensin receptor blocker that blocks the effects of angiotensin II, a hormone that constricts blood vessels and promotes sodium and water retention. The combination of sacubitril and valsartan in LCZ696 provides a dual mechanism of action, targeting both the neurohormonal and renin-angiotensin-aldosterone systems. This drug has shown significant benefits in reducing cardiovascular mortality and hospitalizations for heart failure. It is typically administered orally and is well-tolerated, with common side effects including hypotension, hyperkalemia, and angioedema. LCZ696 has revolutionized the treatment of heart failure and is considered a breakthrough therapy in this field.
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